3 rs animal research

The Institute of Cancer Research strongly supports the principles of the 3Rs – replacement, refinement and reduction of use of animals in research – which have been widely adopted across research … The guiding principles underpinning the humane use of animals in scientific research are called the three Rs. It describes: * Replacement of animals in research with alternative techniques; * Refinement of scientific procedures to enhance animal welfare; * Reduction of the number of animals … and Burch, R.L., (1959). The three Rs are a set of principles that scientists are encouraged to follow in order to reduce the impact of research on animals. The PREPARE guidelines for planning animal research and testing contain links to many resources which can be used to improve applications for animal experiments and implement the 3Rs.. William Russell and Rex Burch developed the concept of the Three Rs during the 1950s, and described them in their book The Principles … It therefore expects that such work is conducted to the highest standards, meeting or exceeding the legal requirements and associated guidance issued by the Home Office. The Home Office statistics for 2011 show that, in the UK, just over 3.7 million animals were used in research, 93% of which were mice, rats or fish. The information provided by Understanding Animal Research … The 3Rs working group . Replacement refers to technologies or approaches which directly replace or avoid the use of The Division of Biomedical Services and associated researchers are actively identifying 3Rs (replacement, refinement and reduction of animals in research) related issues and … The Principles of Humane Experimental Technique, Methuen, London. At UBC we believe that the 3Rs is not always best served by using the fewest number of animals, but rather by ensuring that the fewest possible are used to make meaningful contributions to scientific understanding. The Royal Veterinary College is committed to the principles of the 3Rs of reduction, refinement and replacement. It also requires scientists to think more about how to do this, when also may improve the quality of the scientific findings. the UFAW should undertake a scientific study of humane technique in laboratory animal experiments. In order to test this hypothesis, a literature survey of animal-based research was conducted. Abstract Since the Three Rs of replacement, reduction and refinement was proposed by Russel and Birch in 1959, researchers have a moral duty to minimize harm to animals. Additionally, they have the added benefit of improving the results of the data. The growing understanding that animals are not simply “research tools”, and that better welfare leads to better science, led directly to the concept of the Three R’s—replacement, reduction, and refinement—launched by Russell and Burch in 1959 in their book “The Principles of Humane Experimental Technique” … The principles of the 3Rs are accepted internationally and provide a framework for ethical decision making in the use of animals in research and teaching. The 3Rs are implicit in the AWA and any scientist planning to use animals (except rats, mice, and birds, which are not included in the AWA) in their research must first demonstrate why there is no alternative; and that the number of animals used, and any suffering caused, will be kept to a minimum. The 3Rs are part of the fundamental framework for the ethical, humane and responsible care and use of animals for scientific purposes in Australia. The College recognises that high standards of animal welfare contribute to good scientific outcomes which will in the case of veterinary research, ultimately benefit other animals. Legislation mandating the incorporation of the three Rs into animal research and testing has been passed in the United States and Europe. The 3Rs aim to improve the welfare of animals used in science or education, while advancing the quality of scientific and medical testing. In March 2015 they published a Delivery Report, which describes the progress made on actions set out in the Delivery Plan. Our researchers make every effort to replace research animals with inanimate systems or non-animal models, reduce the number of animals involved, and refine husbandry and experimental procedures to minimize pain and distress. The importance of our moral and legal obligations underpins our culture of care and compliance. When animals are used in research, we are committed to acting ethically and practising good animal welfare. The use of animals is a privilege and animals must be treated respectfully, carefully, and responsibly. What is Laboratory Animal Science and the 3 Rs? Research using animals is a small, yet vital, part in the development of our medicines, vaccines and consumer health products. This material, which was originally produced by the RSPCA in 2012, to help trainers/course providers teach about how “The ‘R’ of Replacement” could be applied to all or part of a project, was refreshed and updated in 2014. The welfare of animals is a primary concern of the College. They don’t ask questions like, “Is the experiment worth pursuing in the first place? Any researcher planning to use animals in their research must first show why there is no alternative and what will be done to minimise numbers and suffering, ie: In 2014 they published Working to reduce the use of animals in research: delivery plan. Replacement alternatives refer to methods which avoid or replace the use of … Tagged: Animals, Research methods, Methods. See ARRIVE guidelines (NC3Rs website) for further information. Replacement refers to the preferred use of non-animal methods over animal use methods in the attainment of a similar level of results. If scientifically valid results can be found by working with more animals on an individual study, this can eliminate the need for further studies and avoid the unnecessary use of more animals in future research. Replacement: Using methods or strategies that replace or avoid the use of animals in research and testing. The laboratory animal science community is committed to the 3 Rs: replacement, reduction and refinement. The three R's have become central to the current ways of understanding and preserving the ethical treatment of animals in research. ISBN 0900767782. David DeGrazia: The three Rs don’t take the costs and benefits of animal research into account. The role of the IACUC is detailed in legislation and binding rules, which are in turn inspired by the Three Rs: the principles of Replacement, Reduction, … The Three Rs are basic principles of humane experimental technique that were first set out by Russell and Burch* in 1959. The Institutional Animal Care and Use Committee (IACUC) is entrusted with assessing the ethics of proposed projects prior to approval of animal research. A key aspect of animal welfare is covered by what the biomedical community refers to as the three Rs … The use of the three Rs in animal testing are principles for the ethical use of animals in testing: Replacement. *Russell, W.M.S. The Three Rs are basic principles of humane experimental technique that were first set out by Russell and Burch* in 1959. The three Rs. 0800 368 9520       jasmin.devivo@plmr.co.uk, 3Rs - Replacement, Refinement and Reduction, The Principles of Humane Experimental Technique, Ethical Review for Practice-based Research - Joint RCVS/BVA Working Party, Working to reduce the use of animals in research: delivery plan, Animal Welfare and Ethical Review Body (AWERB), RVC For All – Visit Us, Widening Participation. … Our current refinement work falls into three main areas: Refining housing, husbandry and procedures to reduce lifetime harms to laboratory animals Promoting effective welfare assessment of laboratory animals, including pain, suffering, distress and positive welfare Although it is aimed at clinical practices, it does provide useful guidance relating to ethical reviews. The role of the IACUC is detailed in legislation and binding rules, which are in turn inspired by the Three Rs: the principles of Replacement, Reduction, and … Available both as a Powerpoint Presentation and as a PDF: Animal Research: Reporting of In Vivo Experiments (ARRIVE) guidelines improve standards of reporting and ensure that the data from animal experiments can be fully evaluated and utilised. It discusses the distinction between clinical practice and clinical research and then considers under what circumstances research requires Home Office authorisation under the Animals Scientific Procedures Act 1986 (ASPA) and when it does not. A report was produced by a Joint RCVS/BVA Working party in 2013. The Institutional Animal Care and Use Committee (IACUC) is entrusted with assessing the ethics of proposed projects prior to approval of animal research. For each project it ensures, as far as is reasonably practicable, that no alternative to the use of animals is possible, that the number of animals used is minimised and that procedures, care routines and husbandry are refined to maximise welfare. reports of the implementation of the Three Rs in animal research papers would have increased during this period. Definition: The Three Rs principle was launched in the early 1960s by two English biologists, Russel and Burch in their book “The Principle of Humane Experimental Technique”. We fund research, support training and development, and stimulate changes in policy, regulations and practice. This body involves lay representation plus external and internal members. The 3 Rs stand for Replacement, Reduction and Refinement. They are accepted internationally, and in Australia through adoption of the Code in state and territory legislation. to methods that avoid or replace the use of animals defined as 'protected' under the Animals (Scientific Procedures) Act 1986 (ASPA) in In 2010, the coalition Government made a commitment to reduce the use of animals in scientific research. While this sounds a lot, to put this number into perspective, this means that for each member of the 63 million strong UK population, 0.06 of an animal was used in research … They are now widely accepted by leading academic journals in biomedical research. The 3R principles remain a fundamental concept in laboratory animal science today, underpinning EU and national legislation on the protection and welfare of animals used for scientific … Reduction: Reducing the number of animals used to achieve the scientific objectives, for example by improving experimental design and statistical analyses. They are now widely accepted within the international scientific community and in associated legislation and guidelines, as a means of avoiding or reducing animal use and suffering and helping to improve the quality of science. This process is undertaken by the College's Animal Welfare and Ethical Review Body (AWERB). All UBC animal researchers are required by the CCAC to follow an evaluative process called the Three Rs: Replacement, Reduction and Refinement. Even though animal experiments are performed by the Three Rs concept, animal researches which do not comply with international … By doing so, researchers reduce the need for animal research subjects. Newer Post What is the difference between mEPSCs and sEPSCs? It provides advice on the application of the 3Rs, matters relating to the welfare and care of animals, management and operational processes within facilities and the suitability of project proposals and subsequent review. They are now widely accepted within the international scientific community and in associated legislation and guidelines, as a means of avoiding or reducing animal use and suffering and helping to improve … Primarily funded by Government, the NC3Rs is also … All UBC animal researchers are required by the CCAC to follow an evaluative process called the Three Rs: Replacement, Reduction and Refinement. The three ‘Rs’ The legislation is underpinned by the three ‘Rs’ – the principles of replacement, reduction and refinement – which ensures that animal research is carried out only where no practicable alternative exists and under conditions which minimise any suffering.

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