resveratrol 500mg side effects

2021/05/21

Additionally, in a randomized, open-label, and controlled study, the effect of oral resveratrol (250 mg/day) on glycemic control and lipid metabolism was assessed in 62 type 2 diabetics (132). High-dose resveratrol supplementation in obese men: an investigator-initiated, randomized, placebo-controlled clinical trial of substrate metabolism, insulin sensitivity, and body composition. Plants make resveratrol to help protect themselves from damage and infections (Salehi, 2018). While exciting, applying resveratrol to cells in a test tube is much different than giving it to people. In humans, short-term supplementation with resveratrol has been associated with beneficial effects on glucose and lipid metabolism in individuals with type 2 diabetes. (PubMed), 62. Nat Prod Commun. (PubMed). 2007;139(3):475-485. naturals mg resveratrol glycine supplement production 1000 energy capsules Interestingly, studies that administered alcohol-free red wine to rodents noted improvements in various parameters related to cardiovascular disease (93, 94), and a placebo-controlled human study found that heart disease patients administered red grape polyphenol extract experienced acute improvements in endothelial function (95). Many of these supplements contain much higher doses of resveratrol than a person would naturally consume in food sources. Be on the lookout for resveratrol in the ingredients list the next time youre shopping for a skincare regimen. A 2015 review concluded that high doses may help reduce the pressure exerted on artery walls when the heart beats (3). Donnelly LE, Newton R, Kennedy GE, et al. FASEB J. Nutr Res. Butcher Box is a grocery delivery service specializing in meat and seafood. (PubMed), 156. (PubMed), 104. Other research in test tubes and animals has suggested that the compound has potential to reduce inflammation and prevent damage to joints (33, 35, 36, 37). By inhibiting COX enzymes that cause inflammation on a cellular level, resveratrol should theoretically help with conditions such as osteoarthritis. The decreased concentrations of two CVD risk markers, oxidized low-density lipoprotein (oxLDL) and apolipoprotein B (ApoB) after six months further suggested a cardioprotective effect of resveratrol (110). 5. Brown, V. A., Patel, K. R., Viskaduraki, M., Crowell, J. The human body metabolizes the compound quickly. Pharmacol Res. Yet, in a pilot study, unmetabolized resveratrol and conjugates have been detected in colorectal tumor tissues from 20 cancer patients following daily oral supplementation with either 4 g or 8 g of resveratrol for 29 days. 2012;56(5):810-821. 2003;348(2):109-118. Endothelial dysfunction is usually associated with the presence of cardiovascular risk factors (e.g., insulin resistance, hypertension, and hypercholesterolemia) and is thought to precede the clinical manifestation of cardiovascular and metabolic disorders. Effects of resveratrol on memory performance, hippocampal functional connectivity, and glucose metabolism in healthy older adults. Antiartherosclerotic effects of plant flavonoids. When too much sorbitol builds up in people with diabetes, it can create cell-damaging oxidative stress (30, 31). Therefore, high intakes of resveratrol (i.e., from supplements) could potentially reduce the metabolic clearance of drugs that undergo extensive first-pass metabolism by CYP3A4, hence increasing the bioavailability and risk of toxicity of these drugs. However, resveratrol intake did not improve performance in cognitively demanding tasks undertaken during the post-administration period (126). 2014;2014:480258. 2008;56(18):8374-8378. Unmetabolized resveratrol was measurable in the liver of five out of six patients who consumed 5 g of SRT501, and SRT501 administration resulted in an increased detection of the apoptotic marker, cleaved caspase-3, in hepatic tumor tissues. Of the limited research in humans, most has focused on supplemental forms of the compound, in concentrations higher than those you could get through food (5). Tome-Carneiro J, Gonzalvez M, Larrosa M, et al. 2013;19(34):6064-6093. Indeed, trans-resveratrol appears to be well absorbed by humans when taken orally, but its bioavailability is relatively low due to its rapid metabolism and elimination (6). Significant reductions in cardiovascular disease risk have been associated with moderate consumption of alcoholic beverages (79). Resveratrol has been studied, especially in test tubes, for its ability to prevent and treat cancer. 2013;160(5):714-717. Platelet aggregation is one of the first steps in the formation of a blood clot that can occlude a coronary or cerebral artery, resulting in myocardial infarction or stroke, respectively. Oregon State University, Reviewed in May 2015 by: This compound tends to be concentrated mostly in the skins and seeds of grapes and berries. However, some people have reported joint pain and tendinitis with resveratrol use. Int J Mol Med. 2003;311(2):546-552. Since then, reports on the potential for resveratrol to prevent cancer, delay the development of cardiovascular and neurodegenerative diseases, improve glycemic control in type 2 diabetes, and extend lifespan in experimental models have continued to generate scientific interest (see Disease Prevention). One major resveratrol derivative is resveratrol-3-O--glucoside, also called piceid (Figure 1) (3). (PubMed), 9. 2014;2(5):500-520. Mol Nutr Food Res. Novel strategies for preventing diabetes and obesity complications with natural polyphenols. Essentially, this means it neutralizes free radicalscompounds that can damage cells if levels become too high. Patel KR, Brown VA, Jones DJ, et al. We know resveratrol is an anti-inflammatory because its an antioxidant, so it affects cells in your body by protecting them from damage. Johansen D, Friis K, Skovenborg E, Gronbaek M. Food buying habits of people who buy wine or beer: cross sectional study. It has antioxidant, anti-inflammatory, and anti-aging effects.

Br J Nutr. Biochem Biophys Res Commun. Salehi, B., Mishra, A. P., Nigam, M., Sener, B., Kilic, M., Sharifi-Rad, M., et al. 2002;76(2):466-472. There are many benefits associated with resveratrol, though they are mostly correlated to the compound rather than directly linked to the consumable supplement. 1999;89(5):685-690. (PubMed), 45. Resveratrol has been found to inhibit the proliferation of VSMCs in culture (45-47), as well as in vivo (48). Am J Clin Nutr. 1996;59(1):PL15-21. Tome-Carneiro J, Gonzalvez M, Larrosa M, et al. (PubMed), 85. (PubMed), 80. 1999;126(3):673-680.

2005;49(5):405-430. 2015;22(1):150-164.

These benefits include increasing insulin sensitivity and preventing complications from diabetes (26, 27, 28, 29). A few clinical studies have evaluated the effects of resveratrol on key metabolic variables in overweight or obese subjects with no overt metabolic dysfunction and found little or no metabolic benefits following resveratrol treatment (134-136).

There is some resveratrol in white wine, but red wine contains three to 10 times more resveratrol compared to white wine.. Resveratrol also reduced senile plaque counts in various brain regions of a transgenic AD mouse model (61). J Am Soc Hortic Sci. Yeast Sir2 is a nicotinamide adenine dinucleotide (NAD)-dependent deacetylase enzyme that removes the acetyl group from acetylated lysine residues in target proteins (see the article on Niacin). Human studies are limited and have found mixed results. cardiovascular vitamins alfa capsules resveratrol prevent supports damage powerful brain function mg cell help health aging metabolism effects anti Am J Clin Nutr. Whether increased consumption of polyphenols from red wine provides any additional cardiovascular benefits beyond those associated with red wines alcohol content needs to be further examined (see the article on Alcoholic Beverages) (96). Ruszkiewicz J, Albrecht J. (2018). Nutr Res. Food Chem. 1995;235(2):207-219. Brito P, Almeida LM, Dinis TC. (PubMed), 116. Steady-State pharmacokinetics and tolerability of trans-resveratrol 2000 mg twice daily with food, quercetin and alcohol (ethanol) in healthy human subjects. (PubMed), 49. These structural changes were associated with significant improvements in spatial learning, memory formation, and mood function (56). Clinical trials show that it is technically safe to take resveratrol in doses of up to 5 g per day, though taking more than 2.5 g per day is likely to result in abdominal side effects, such as cramping, flatulence, nausea, and more. (PubMed), 29. (PubMed), 154. However, its not clear if the compound would have a similar effect in humans. (PubMed), 73. 2010;299(5):H1451-1458. However, there is little evidence that resveratrol is an important antioxidant in vivo. Ma T, Tan MS, Yu JT, Tan L. Resveratrol as a therapeutic agent for Alzheimer's disease. Boca Raton: CRC Press; 2005:449-463. Get a little serving of equity in your feed with these 6 dietitians. Karatzi K, Karatzis E, Papamichael C, Lekakis J, Zampelas A. Antihyperglycemic effects of short term resveratrol supplementation in type 2 diabetic patients. Goldberg DM, Karumanchiri A, Ng E, Yan J, Eleftherios P, Soleas G. Direct gas chromatographic-mass spectrometric method to assay cis-resveratrol in wines: preliminary survey of its concentration in commercial wines. Cell Metab. 2002;115(3):378-380. J Agric Food Chem. 2000;66(8):663-673. (PubMed), 61. Yet, at present, there is no available evidence to suggest whether overweight or obese individuals with impaired glucose tolerance could benefit from resveratrol supplements and reduce their risk of developing type 2 diabetes (137). Safety studies conducted on high-purity trans-resveratrol in experimental animals. Creasey LL, Coffee M. Phytoalexin production potential of grape berries. 2011;106(3):383-389. We link primary sources including studies, scientific references, and statistics within each article and also list them in the resources section at the bottom of our articles. Wilson T, Knight TJ, Beitz DC, Lewis DS, Engen RL. Inhibition of human LDL oxidation by resveratrol. Ramrez-Garza, S. L., Laveriano-Santos, E. P., Marhuenda-Muoz, M., Storniolo, C. E., Tresserra-Rimbau, A., Vallverd-Queralt, A., et al. Impaired glucose tolerance is associated with insulin resistance in skeletal muscle the major peripheral tissue for insulin-mediated glucose uptake as well as defective insulin secretion by pancreatic -cells. Howitz KT, Bitterman KJ, Cohen HY, et al. To fuel their rapid growth, invasive tumors must also develop new blood vessels by a process known as angiogenesis. (PubMed), 15. Resveratrol is found in grapes, wine, grape juice, peanuts, cocoa, and berries of Vaccinium species, including blueberries, bilberries, and cranberries (140-143). 2015;34(1):27-34. 1999;56(4):760-767. But these higher doses cannot be reached by diet alone and are usually reached when you consume supplements. The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: implications for protection against coronary heart disease. Heres how resveratrol may combat cancer cells: However, since the studies so far have been carried out in test tubes and animals, much more research is needed to see if and how this compound might be used for human cancer therapy. (PubMed), 6. Resveratrol is an antioxidant-like compound found in red wine, berries and peanuts. Am J Epidemiol. 2012;107(6):774-780. Clinical pharmacology of resveratrol and its metabolites in colorectal cancer patients. While resveratrol supplements are likely safe for most people, they could interact with certain medications and theres not yet clear guidance on how to use them effectively. While some large prospective cohort studies found that wine drinkers were at lower risk of cardiovascular disease than beer or liquor drinkers (82-84), others found no difference (85-87). (PubMed), 115. (PubMed), 131. Yoshino J, Conte C, Fontana L, et al. (PubMed), 132. (PubMed), 2. 2001;39(1):102-107.

Leonard SS, Xia C, Jiang BH, et al. (PubMed), 135. Consejo Superior de Investigaciones Cientficas (CSIC) 1992;43(1):49-52. Resveratrol is a powerful antioxidant with great potential. Resveratrol has also exhibited additional neuroprotective properties in cultured cells and animal models (see Biological Activities). Food Chemistry. JAMA Intern Med. Bradamante S, Barenghi L, Villa A. Cardiovascular protective effects of resveratrol. Effects of red wine on endothelial function: postprandial studies vs clinical trials.

2002;50(11):3337-3340.

Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients. BMJ. Exactly what impact do they have on the, This article identifies the 15 most healthful foods based on recent research. Cancer prevention and treatment with resveratrol: from rodent studies to clinical trials. Chow HH, Garland LL, Hsu CH, et al. One randomized, placebo-controlled study in healthy overweight or obese volunteers (BMI, 25-34 kg/m2) found that a single dose of trans-resveratrol (30 mg, 90 mg, or 270 mg) improved brachial FMD around 60 minutes after administration (106). Repeated doses of 1 g/day of trans-resveratrol (a dose less likely to cause side effects; see Safety) could yield maximum plasma concentrations of about 22 M for resveratrol-3-O-sulfate (the most abundant sulfate conjugate in humans) and about 7-8 M for typical monoglucuronide conjugates (12). 2015;177:165-173. Yurdagul A, Jr., Kleinedler JJ, McInnis MC, et al. Grape resveratrol increases serum adiponectin and downregulates inflammatory genes in peripheral blood mononuclear cells: a triple-blind, placebo-controlled, one-year clinical trial in patients with stable coronary artery disease. (PubMed), 118. 2003;309(4):1017-1026. Vaz-da-Silva M, Loureiro AI, Falcao A, et al. You may hyperlink to this website but must include the following statement: "This link leads to a website provided by the Linus Pauling Institute at Oregon State University. Concentration of the phytoalexin resveratrol in wine. The proper dosage of resveratrol is unclear and remains under debate by medical professionals. 2004;25(10):2005-2013. Semin Thromb Hemost. 23. 2003;64(5):1029-1036.

In addition, resveratrol may serve as a therapeutic agent for rheumatoid arthritis, as well as for male infertility and testicular malfunction. Stervbo U, Vang O, Bonnesen C. A review of the content of the putative chemopreventive phytoalexin resveratrol in red wine. J Cardiovasc Pharmacol. Biomed Res Int. Food Sci Nutr. However, clear dosage guidance is still lacking. More research is needed, as most of the above studies were animal studies. Fukao H, Ijiri Y, Miura M, et al. Chronic resveratrol consumption improves brachial flow-mediated dilatation in healthy obese adults. To benefit from resveratrol, Zumpano suggests working 1 gram of resveratrol into your diet each day, and that its important this comes from natural sources. (PubMed), 123. (PubMed), 159. At present, little is known about the biological activity of resveratrol metabolites. (PubMed), 44. (PubMed), 139. J Agric Food Chem. Wannamethee SG, Shaper AG. Liu Y, Ma W, Zhang P, He S, Huang D. Effect of resveratrol on blood pressure: A meta-analysis of randomized controlled trials. 2005-2022 Healthline Media a Red Ventures Company. (13) thoroughly reviewed the most relevant preclinical studies published in the most recent decades. 2009;2(5):409-418. Changes in the mitochondrial antioxidant systems in neurodegenerative diseases and acute brain disorders. Cardiovasc Drug Rev. (PubMed), 98. 149. Br J Haematol. Absorption of three wine-related polyphenols in three different matrices by healthy subjects. Diabetes Res Clin Pract. Andy Baraghani shares the dish that found him love. Rimm EB, Klatsky A, Grobbee D, Stampfer MJ. Pediatrics. 2010;36(1):59-70. Lekakis J, Rallidis LS, Andreadou I, et al. Capiralla H, Vingtdeux V, Zhao H, et al. (PubMed), 111. 2010;30(8):1103-1114. Linus Pauling Institute 2013;5(205):205ra133. 130. Resveratrol is also a phytoalexin, which is a protective antibiotic that plants produce under stress. You have successfully subscribed to our newsletter. Its unlikely a resveratrol supplement would cause harmespecially when taken at the recommended dose. (PubMed), 153. (PubMed), 36. When high, its a risk factor for heart disease. However, researchers are studying ways of making resveratrol easier for the body to use (6, 52). Researchers are investigating if resveratrol can help prevent or treat numerous conditions, including heart disease, cancer, and dementia. Activity in vitro of resveratrol on granulocyte and monocyte adhesion to endothelium. (PubMed), 41. Eur J Pharmacol. Studies have found an association between increased levels of IGF-1 and the risk of colorectal, prostate, lung, and breast cancer (Brown, 2010). 2012;110(3):356-363. Bishayee A. Most recently, resveratrol was shown to improve endothelial wound healing through an ER-dependent pathway in an animal model of arterial injury (24). Klinge CM, Blankenship KA, Risinger KE, et al. These include certain blood pressure medications, anxiety meds and immunosuppressants (50).

Atlanta, GA: US Department of Health and Human Services. Hendler SS, Rorvik DR, eds, eds. 2011;21(11):851-856. As an antioxidant, it also may decrease the oxidation of bad LDL cholesterol. Because of its antioxidant properties, resveratrol could be a promising supplement for lowering blood pressure (9). Nature. Healthy people seem to tolerate them well (47). The recommended dose of resveratrol is not conclusive, but high quantities may lead to gastrointestinal upset. https://pubmed.ncbi.nlm.nih.gov/20935227/, https://pubmed.ncbi.nlm.nih.gov/24073011/, https://pubmed.ncbi.nlm.nih.gov/30513922/, https://pubmed.ncbi.nlm.nih.gov/29737899/, https://pubmed.ncbi.nlm.nih.gov/24111838/, https://pubmed.ncbi.nlm.nih.gov/30205595/, https://pubmed.ncbi.nlm.nih.gov/27422505/. Howells LM, Berry DP, Elliott PJ, et al. Youll typically see doses listed as milligrams (mg) of trans-resveratrolan active form of the chemical. Drug Metab Dispos. Kennedy DO, Wightman EL, Reay JL, et al. Research most supports its use for cardiovascular protection and blood pressure regulation. Repeat dose study of the cancer chemopreventive agent resveratrol in healthy volunteers: safety, pharmacokinetics, and effect on the insulin-like growth factor axis. (PubMed), 16. la Porte C, Voduc N, Zhang G, et al. Resveratrol is a compound that belongs to polyphenols stilbenoids group, consisting of two phenol rings that are connected by an ethylene bridge. (PubMed), 127. Walle T, Hsieh F, Delegge MH, Oatis JE, Jr., Walle UK. Am J Physiol Lung Cell Mol Physiol. 2010;3(9):1168-1175. Defective cell cycle regulation may result in the propagation of mutations that contribute to the development of cancer. J Neurosci. Biochem Biophys Res Commun. More than one out of three American adults has impaired glucose tolerance (also known as prediabetes), which places them at increased risk of developing type 2 diabetes (129). Some berries (e.g., cranberries, blueberries, and raspberries) and peanuts also contain resveratrol in lower concentrations (Ratz-yko, 2019). Antagonists of the estrogen hormone bind to receptor sites, blocking the effects of the hormone. Animal and lab studies have shown that resveratrol may positively affect cholesterol levels (Sahebkar, 2013). Youve heard an apple a day keeps the doctor away, but a glass of wine or even a glass of grape juice could keep you feeling healthy in a variety of ways, thanks to a key ingredient known as resveratrol. (PubMed), 37. National Diabetes Statistics Report: Estimates of Diabetes and Its Burden in the United States, 2014. 2009;4(5):635-658. Resveratrol has been found to inhibit the activity of at least one type of matrix metalloproteinase (30, 31). This suggests that resveratrol may interfere with CYP1A2-mediated drug metabolism by increasing drug clearance, possibly lowering circulating drug concentrations below therapeutic levels. J Biol Chem. (PubMed), 155. Resveratrol has been found to increase the expression and activity of NAD(P)H:quinone oxidoreductase-1 (NQO1) in cultured cells (27) and may be a weak inducer of other phase II enzymes (28). Resveratrol has been found to inhibit the activity of several inflammatory enzymes in vitro, including cyclooxygenases and lipoxygenases (37, 38). Heart Fail Rev. Resveratrol may interact with several medications. Evaluation of butylated hydroxyanisole, myo-inositol, curcumin, esculetin, resveratrol and lycopene as inhibitors of benzo[a]pyrene plus 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in A/J mice. Biochem Biophys Res Commun. 2006;444(7117):337-342. However, in cell culture experiments, resveratrol was found to act either as an estrogen agonist or as an estrogen antagonist depending on such factors as cell type, estrogen receptor isoform (ER or ER), and the presence of endogenous estrogens (23). Tome-Carneiro J, Gonzalvez M, Larrosa M, et al. 2008;46(11):564-570. Insulin-like growth factor-1 (IGF-1) is a naturally occurring hormone in your body. Mild diarrhea was also reported in six out of eight individuals who consumed 2,000 mg of resveratrol twice daily for two periods of eight days in an open-label and within subject-control study (16). PDR for Nutritional Supplements. Its reasonably well tolerated up to 5 grams per day. J Agric Food Chem. 2013;166(1):246-248. In one study, participants were given grape extract that had been boosted with extra resveratrol. 1999;159(16):1865-1870. (PubMed), 52. 2013;1290:37-51. Resveratrol prevents age-related memory and mood dysfunction with increased hippocampal neurogenesis and microvasculature, and reduced glial activation. Resveratrol has been found to inhibit angiogenesis in vitro (32-34) and in vivo (35). Resveratrol is a polyphenol antioxidant that may help to prevent heart disease, cancer, diabetes, and early signs of aging. Stewart ZA, Westfall MD, Pietenpol JA. Mnjoyan ZH, Fujise K. Profound negative regulatory effects by resveratrol on vascular smooth muscle cells: a role of p53-p21(WAF1/CIP1) pathway. 2014;34(23):7862-7870. (PubMed), 86. 2015; doi: 10.1016/j.neuint.2014.12.012. J Agric Food Chem. Aggarwal BB, Bhardwaj A, Aggarwal RS, Seeram NP, Shishodia S, Takada Y. Caloric restriction is known to extend the lifespan of a number of species, including yeast, worms, flies, fish, rats, and mice (115). J Hypertens. Some people also take resveratrol supplements, especially for lowering blood pressure. Resveratrol was found to facilitate the clearance of -amyloid peptide and promote cell survival in primary neurons in culture and neuronal cell lines (58-60). Cancer Prev Res (Phila). (PubMed), 105. 1995;43(5):1245-1250. Diabetes. We do not endorse non-Cleveland Clinic products or services. Resveratrol may help relieve joint pain by preventing cartilage from breaking down. 2014;19(11):17154-17172. 1997;30(2):91-113. J Agric Food Chem. Steele VE, Hawk ET, Viner JL, Lubet RA. Studies have indicated nausea, diarrhea, vomiting and other gastrointestinal issues can occur when consuming higher doses. Experimental studies: Resveratrol has been found to exert a number of protective effects on the cardiovascular system in vitro, including inhibition of both platelet activation and aggregation (53, 98, 99), promotion of vasodilation by enhancing the production of nitric oxide (NO) (52), and control of the production of inflammatory lipid mediators (38, 100, 101).

Antiplatelet activity of synthetic and natural resveratrol in red wine. Semba RD, Ferrucci L, Bartali B, et al. Resveratrol for primary prevention of atherosclerosis: clinical trial evidence for improved gene expression in vascular endothelium. Red wine contains variable and usually low concentrations of resveratrol (see Sources) and higher concentrations of flavonoids like procyanidins. Researchers say they aren't sure how closely connected grip strength and dementia are, but the link may have something to do with overall physical. One study has reported that bioavailability of trans-resveratrol from red wine did not differ when the wine was consumed with a meal (low- or high-fat) versus on an empty stomach (14). This article explains what you need to know about resveratrol, including seven of its main potential health benefits. Chemoprevention by resveratrol: molecular mechanisms and therapeutic potential. Resveratrol is a plant compound that acts like an antioxidant. In Vivo. Although resveratrol bioavailability to the brain is uncertain (78), a randomized, double-blind, placebo-controlled study has reported an increase in cerebral blood flow in the prefrontal cortex of healthy young subjects (ages, 18-29 years) following a single oral dose of 500 mg of resveratrol. Lin SJ, Defossez PA, Guarente L. Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. (PubMed), 32. Yet, it appears that resveratrol content in wine is usually low, highly variable and unpredictable, and resveratrol is only a minor compound in the complete set of grape and wine polyphenols (13). (PubMed), 21. 2009;19(10):744-750. 2003;158(6):585-595. Some animal studies also suggested that high oral doses of resveratrol could decrease the risk of thrombosis and atherosclerosis (102, 103), although one study found increased atherosclerosis in animals fed resveratrol (104). Phytopharmaceuticals in Cancer Chemoprevention. Most notably, it helps with brain and heart inflammation by providing a protective lining for your blood vessels and preventing insult or injury. Although rare, anecdotal gastrointestinal side effects have been reported by resveratrol users. Healthline Media does not provide medical advice, diagnosis, or treatment. J Biol Chem. This can increase your chance of a heart attack. Resveratrol inhibits phorbol myristate acetate-induced matrix metalloproteinase-9 expression by inhibiting JNK and PKC delta signal transduction. 2004;23(10):1845-1853. That means some medications could build up to unsafe levels. Takahashi S, Nakashima Y. However, they are not a substitute for professional medical advice, diagnosis, or treatment. More research is needed to support these claims. Resveratrol seems to influence cholesterol levels by reducing the effect of an enzyme that controls cholesterol production (13). A 2016 study fed mice a high-protein, high-polyunsaturated fat diet and also gave them resveratrol supplements. 144. (PubMed), 19. After six months of treatment, their LDL had gone down by 4.5% and their oxidized LDL had gone down by 20% compared to participants who took an unenriched grape extract or a placebo (15). Brown VA, Patel KR, Viskaduraki M, et al. Inhibition of vascular endothelial growth factor-induced angiogenesis by resveratrol through interruption of Src-dependent vascular endothelial cadherin tyrosine phosphorylation.