If antacids must be used while a

2021/05/21

If antacids must be used while a patient is taking glyburide, give the glyburide at least 2 hours prior to the antacid. In a single-dose crossover study in healthy volunteers, coadministration of tacrolimus and magnesium-aluminum-hydroxide resulted in a mean AUC increase of 21% and a 10% decrease in the mean tacrolimus Cmax, compared to tacrolimus administration alone. Canada residents can call a provincial poison control center. Fexofenadine: (Moderate) Coadministration with antacids (containing aluminum or magnesium) within 15 minutes decreases the AUC and Cmax of fexofenadine by 41% and 43%, respectively. Hydrocodone; Pseudoephedrine: (Minor) Concurrent use of hydrocodone with strong laxatives that rapidly increase gastrointestinal motility, such as magnesium hydroxide, may decrease hydrocodone absorption. It may be advisable to separate chlorpromazine administration from antacids by 1 to 2 hours. Patients at increased risk of aluminum accumulation include patients with renal impairment or renal failure. Administer eltrombopag at least 2 hours before or 4 hours after any oral products containing polyvalent cations, such as aluminum salts, (like aluminum hydroxide), calcium salts, (including calcium carbonate), and magnesium salts. Abacavir; Dolutegravir; Lamivudine: (Moderate) Administer dolutegravir 2 hours before or 6 hours after taking cation-containing antacids. Closely monitor patients for changing analgesic requirements or adverse events. Patients at increased risk of aluminum accumulation include patients with renal impairment or renal failure. Acetaminophen; Dextromethorphan; Guaifenesin; Pseudoephedrine: (Minor) Antacids can delay the oral absorption of acetaminophen, but the interactions are not likely to be clinically significant as the extent of acetaminophen absorption is not appreciably affected. Increasing the dose of erlotinib without modifying the administration schedule is unlikely to compensate for loss of exposure. (Major) Administer oral delafloxacin at least 2 hours before or 6 hours after products that contain magnesium hydroxide. Take this medication by mouth, usually after meals and at bedtime as needed. Etidronate: (Moderate) Separate administration of oral etidronate and aluminum hydroxide by at least 2 hours. Tipranavir: (Moderate) Concurrent administration of tipranavir and ritonavir with antacids results in decreased tipranavir concentrations. Conversely, exposure to itraconazole is increased when antacids are administered with the 65 mg itraconazole capsule. The chemical structure of these antacids contains aluminum or magnesium which can bind cabotegravir in the GI tract. If hypokalemia occurs or persists, consider reducing the dichlorphenamide dose or discontinuing dichlorphenamide therapy. (Moderate) Administer dolutegravir 2 hours before or 6 hours after taking cation-containing gastrointestinal medications such as magnesium hydroxide. Acetaminophen; Oxycodone: (Minor) Antacids can delay the oral absorption of acetaminophen, but the interactions are not likely to be clinically significant as the extent of acetaminophen absorption is not appreciably affected. Antacids may decrease the absorption of oral iron preparations. Taking these drugs simultaneously may result in reduced bioavailability of dolutegravir. Other orally administered aluminum or magnesium salts may also interfere with cefditoren absorption. Ticlopidine: (Major) Administration of ticlopidine after antacids resulted in an 18% decrease in plasma levels of ticlopidine. Taking these drugs simultaneously may result in reduced bioavailability of dolutegravir. If aluminum-based antacids are used on a regular basis, an alternative to pseudoephedrine may be considered. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. Antacids containing alkalinizing agents such as sodium bicarbonate can alkalinize the urine, thereby decreasing the effectiveness of methenamine by increasing the amount of non-ionized drug available for renal tubular reabsorption. aluminum hydroxide) because a reduction in cholic acid absorption will occur. Our Pharma Division deals only with the best, GMP certified generics and branded medication for the export market. Separate the administration of bosutinib and antacids by more than 2 hours. The aluminum in this product can cause constipation. In general, it may be prudent to avoid drugs such as antacids in combination with enteric-coated budesonide. Keep all regular medical and laboratory appointments. Fosamprenavir: (Moderate) The administration of an aluminum hydroxide and magnesium hydroxide containing antacid with fosamprenavir decreased fosamprenavir Cmax and AUC. If aluminum-based antacids are used on a regular basis, an alternative to pseudoephedrine may be considered. Chlorpheniramine; Hydrocodone: (Minor) Concurrent use of hydrocodone with strong laxatives that rapidly increase gastrointestinal motility, such as magnesium hydroxide, may decrease hydrocodone absorption. This survey is being conducted by the WebMD marketing sciences department. The increase in gastric pH inhibits the proteolytic action of pepsin, an effect that is particularly important in patients with peptic ulcer disease. Protect from light and moisture. The need to stagger doses of propranolol has not been established, but may be prudent. Approximately 15-30% of the magnesium chloride is absorbed and rapidly excreted by the kidneys in patients with normal renal function. The mechanisms by which antacids reduce phenytoin absorption may involve increased gastric transit time, chelation, adsorption, and/or altered solubility. This interaction can be avoided by separating the administration of pseudoephedrine and antacids by 1 to 2 hours. To decrease the risk of virologic failure, avoid use of antacids for at least 2 hours before and at least 4 hours after administering rilpivirine. Aluminum-containing antacids will interfere with the absorption of oral risedronate. Chlorpheniramine; Dextromethorphan; Pseudoephedrine: (Minor) It appears that antacids containing aluminum hydroxide may increase pseudoephedrine plasma concentrations. Atazanavir; Cobicistat: (Major) It is recommended that antacids not be given at the some time as atazanavir because of potential interference with absorption of atazanavir. (Minor) Antacids may decrease the peak plasma concentration (Cmax) of total ezetimibe by 30%. If aluminum-based antacids are used on a regular basis, an alternative to pseudoephedrine may be considered. Vitamin D: (Moderate) The chronic use of aluminum-containing antacids (e.g., aluminum hydroxide-containing antacids) for hyperphosphatemia in conjunction with vitamin D can lead to aluminum retention and possible toxicity. Brompheniramine; Pseudoephedrine; Dextromethorphan: (Minor) It appears that antacids containing aluminum hydroxide may increase pseudoephedrine plasma concentrations.

Naproxen: (Minor) Concomitant administration of antacids can delay the absorption of naproxen. This interaction can be avoided by separating the administration of pseudoephedrine and antacids by 1 to 2 hours. Glyburide; Metformin: (Moderate) Antacids have been reported to increase the absorption of non-micronized glyburide, enhancing their hypoglycemic effects. (Minor) It appears that antacids containing aluminum hydroxide may increase pseudoephedrine plasma concentrations. Taking these drugs simultaneously may result in reduced bioavailability of dolutegravir. Sotorasib: (Moderate) Avoid coadministration of sotorasib and gastric-reducing agents, such as antacids. The extended-release suspension may be taken without regard to antacids containing aluminum or magnesium. Magnesium citrate should not be used chronically as a laxative due to the risk of hypermagnesemia. Gabapentin: (Moderate) Gabapentin should be taken at least 2 hours after the administration of antacids. Increased urine alkalinity also can inhibit the conversion of methenamine to formaldehyde, which is the active bacteriostatic form; concurrent use of methenamine and urinary alkalizers is not recommended. Weight Loss for Health and Longevity, Science Reveals How Red Meat Harms the Heart, Flavored Vapes Still in Stores Despite Federal Ban, New COVID Antiviral Pills: What You Need to Know, Dr. Whyte's Book: Take Control of Your Cancer Risk, WebMD Loses Cherished Leader Kristy Hammam, Health News and Information, Delivered to Your Inbox, Treating Opioid Use Disorder With Medications, Constipated? Our Terms and Conditions and Privacy Policy have recently been updated. (Major) Magnesium hydroxide inhibits the absorption of ethotoin. At higher pH values, iron is more readily ionized to its ferric state and is more poorly absorbed. This increased pressure minimizes the amount of reflux to the esophagus.-Magnesium Hydroxide: Magnesium hydroxide rapidly reacts with gastric acid to form water and magnesium chloride, which neutralizes gastric acid and increases the gastric pH. If aluminum-based antacids are used on a regular basis, an alternative to pseudoephedrine may be considered. The increased pH and decreased pepsin production helps in the healing of peptic ulcers. Aluminum hydroxide; magnesium hydroxide; simethicone should be used cautiously in geriatric patients and in patients with renal impairment or renal disease because of the increased risk of developing hypermagnesemia and magnesium toxicity and aluminum toxicity, especially dialysis dementia in dialysis patients with long term use of aluminum containing antacids. Naproxen; Pseudoephedrine: (Minor) Concomitant administration of antacids can delay the absorption of naproxen. Separating adminisration times may help limit any possible interaction. An increase in adverse reactions was not noted. Atropine; Difenoxin: (Moderate) Diphenoxylate can decrease GI motility. Consult your pharmacist or local waste disposal company. Although the exact mechanism is not known, theoretically it may be due to alterations in gastric pH. Coadministration of aluminum/magnesium hydroxide and bazedoxifene decreased Cmax of bazedoxifene by 8% and increased AUC of bazedoxifene by 7%. Due to the formation of ionic complexes in the gastrointestinal tract, simultaneous administration results in lower elvitegravir plasma concentrations. Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine: (Minor) Antacids can delay the oral absorption of acetaminophen, but the interactions are not likely to be clinically significant as the extent of acetaminophen absorption is not appreciably affected. The effect of the antacids in this regard is not expected to have a significant effect on the ability of ezetimibe to lower cholesterol. Measure potassium concentrations at baseline and periodically during dichlorphenamide treatment. Although this finding is of marginal clinical significance, patients should be monitored for adverse effects in this situation. Ask your pharmacist if you have any questions about your product or its use. This may lead to increased amphetamine concentrations. The chemical structure of these GI drugs that contain polyvalent cations, such as magnesium hydroxide, can bind dolutegravir in the GI tract. Periodic antacid use should not be problematic as long as the antacid and enteric-coated naproxen administration are separated by at least 2 hours. If used in patients with impaired renal function or at high doses for extended periods of time, patients are at risk for developing hypermagnesemia and accumulating aluminum in the bones, lungs, and nerve tissues. Increased urine alkalinity also can inhibit the conversion of methenamine to formaldehyde, which is the active bacteriostatic form; concurrent use of methenamine and urinary alkalizers is not recommended.

Nausea, constipation, diarrhea, or headache may occur. Pancrelipase: (Major) The effectiveness of gastrointestinal enzymes can be diminished with concurrent administration of antacids. General Administration InformationFor storage information, see the specific product information within the How Supplied section.Route-Specific AdministrationOral AdministrationNOTE: The composition of available products (i.e., chewable tablets and oral suspension) is variable. Concomitant use of oral budesonide and antacids, milk, or other drugs that increase gastric pH levels can cause the coating of the granules to dissolve prematurely, possibly affecting release properties and absorption of the drug in the duodenum. In the study, the pharmacokinetics of mefloquine were determined after receiving a single oral mefloquine 500 mg dose alone and after 3-days of cimetidine 400 mg PO bid. This interaction can be avoided by separating the administration of pseudoephedrine and antacids by 1 to 2 hours. Increased urine alkalinity also can inhibit the conversion of methenamine to formaldehyde, which is the active bacteriostatic form; concurrent use of methenamine and urinary alkalizers is not recommended. Does Liquid Antacid Suspension interact with other medications? Antacids containing alkalinizing agents such as sodium bicarbonate can alkalinize the urine, thereby decreasing the effectiveness of methenamine by increasing the amount of non-ionized drug available for renal tubular reabsorption. This decrease in bioavailability was about 5% when gabapentin was administered 2 hours after the antacid. Chlorpromazine: (Moderate) The absorption of chlorpromazine liquids, suspensions, or concentrates may be decreased by co-administration of antacids. Budesonide: (Moderate) Enteric-coated budesonide granules dissolve at a pH more than 5.5. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. An interval of at least 2 hours is advisable between administration of sodium fluoride and aluminum hydroxide. Consult your doctor before breast-feeding. This site complies with the HONcode standard for trustworthy health information: verify here. Examples of compounds that may interfere with quinolone bioavailability include antacids that contain aluminum hydroxide. Acetaminophen; Chlorpheniramine; Phenylephrine : (Minor) Antacids can delay the oral absorption of acetaminophen, but the interactions are not likely to be clinically significant as the extent of acetaminophen absorption is not appreciably affected. Cefuroxime: (Moderate) Antacids can interfere with the oral absorption of cefuroxime axetil and may result in reduced antibiotic efficacy. Carbinoxamine; Hydrocodone; Pseudoephedrine: (Minor) Concurrent use of hydrocodone with strong laxatives that rapidly increase gastrointestinal motility, such as magnesium hydroxide, may decrease hydrocodone absorption. Antacids containing alkalinizing agents such as sodium bicarbonate can alkalinize the urine, thereby decreasing the effectiveness of methenamine by increasing the amount of non-ionized drug available for renal tubular reabsorption. Fexofenadine; Pseudoephedrine: (Moderate) Coadministration with antacids (containing aluminum or magnesium) within 15 minutes decreases the AUC and Cmax of fexofenadine by 41% and 43%, respectively. (Moderate) Concurrent administration of rilpivirine and antacids may significantly decrease rilpivirine plasma concentrations, potentially resulting in treatment failure. In a small study (n = 6), administration of a magnesium trisilicate and aluminum hydroxide liquid gel antacid with a chlorpromazine liquid suspension resulted in a statistically significant decrease in chlorpromazine concentrations (average 20% decline; approximate range: 6% to 48%). WebMD does not provide medical advice, diagnosis or treatment. If your doctor has directed you to use this medication, remember that your doctor has judged that the benefit to you is greater than the risk of side effects. Enter your medication into the WebMD interaction checker, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Fitness vs. Separate doses of atenolol and aluminum-containing antacids or supplements when possible by at least 2 hours to minimize this potential interaction. More hydrogen ions are lost from the stomach than are lost from the intestine, resulting in metabolic alkalosis. Taking these drugs simultaneously may result in reduced oral bioavailability of cabotegravir. This interaction can be avoided by separating the administration of pseudoephedrine and antacids by 1 to 2 hours. Ciprofloxacin: (Moderate) Administer oral ciprofloxacin at least 2 hours before or 6 hours after magnesium hydroxide. Likewise, the dissolution of the coating of extended-release budesonide tablets (Uceris) is pH dependent. Norethindrone; Ethinyl Estradiol; Ferrous fumarate: (Moderate) Doses of antacids and iron should be taken as far apart as possible to minimize the potential for interaction. At higher pH values, iron is more readily ionized to its ferric state and is more poorly absorbed. Chenodiol: (Moderate) Aluminum hydroxide based antacids have been shown to adsorb bile acids in vitro and are expected to interfere with the efficacy of chenodiol. Administer antacids at least 2 hours before or 2 hours after the 100 mg capsule or 200 mg tablet. Consider closely monitoring blood glucose concentrations. Bosutinib: (Moderate) Bosutinib displays pH-dependent aqueous solubility; therefore, concomitant use of bosutinib and antacids may result in decreased plasma exposure of bosutinib. Ethacrynic Acid: (Moderate) Loop diuretics may increase the risk of hypokalemia especially in patients receiving prolonged therapy with laxatives. Dichlorphenamide increases potassium excretion and can cause hypokalemia and should be used cautiously with other drugs that may cause hypokalemia including laxatives. In general, it would be illogical to concurrently administer these drugs at the same time. Taking these drugs simultaneously may result in reduced bioavailability of dolutegravir. If you are taking this product on a regular schedule and miss a dose, take it as soon as you remember.