2021/05/21

On Saturday, the National Coalition of STD Directors urged the Biden administration to follow WHOs lead and declare monkeypox a national public health emergency. We believe this will mobilize the world to act together.

While the administration has taken steps to address the monkeypox outbreak including accelerating the distribution of vaccines and allocating critical funding for monkeypox research, it quite simply is not enough, David C. Harvey, the groups executive director, said in a statement. Accessed July 24, 2022. Tedros said that one of the reasons he moved to declare a global health emergency is the potential for stanching the outbreak, which is overwhelmingly concentrated in men who have sex with men. VB. Date Lab: They both agree that he is definitely a talker. To prepare for potential deliberate biological threats, the US has stockpiled 100 million ACAM2000 doses and 36000 JYNNEOS doses and is seeking to amass more. The decision means the world is now confronting two viral diseases that have crossed the extraordinary threshold of being declared health emergencies: covid-19 and monkeypox. On Friday, the United States identified its first two monkeypox cases in children.

The industry leader for online information for tax, accounting and finance professionals. JP, Barkati Updated July 22, 2022. The pediatric cases, detected this week in an infant and a toddler, are probably the result of household transmission, according to the CDC. Rigorous clinical trials are needed to evaluate the efficacy of antiviral drugs for treating MPXV infection. Reporting from the frontiers of health and medicine, You've been selected! Updated July 22, 2022. Experts believe close contact during male-to-male sexual activity is a major driver of transmission in the ongoing outbreak. Our Standards: The Thomson Reuters Trust Principles. Second meeting of the International Health Regulations (2005) (IHR) Emergency Committee regarding the multi-country outbreak of monkeypox. P, Please check and try again. Infected patients may remain contagious until rashes resolve, up to 4 weeks, which could create challenges for self-isolation, especially if individuals lack adequate housing and income. Screen for heightened risk individual and entities globally to help uncover hidden risks in business relationships and human networks. Public health control must include measures to identify and contain the spread of MPXV within and outside MSM populations. EM, Rao The zoonotic virus, which causes flu-like symptoms and rashes that spread across the body, has been around for decades and is endemic in parts of Africa. Preventing the virus from spreading to more vulnerable populations is important to limit illness, prevent death, and avoid further strain on health systems. Its an ongoing but a very active conversation at HHS.. Exclusive analysis of biotech, pharma, and the life sciences. et al. Countries with production capacity for drugs and vaccines were urged to increase and share output. When the group met in June, the breakdown was 11 against and three for. See here for a complete list of exchanges and delays. MPXV has features more amenable to containment than SARS-CoV-2 because MPXV transmission occurs via close contact and after symptom onset. It needs coordination and not only coordination but solidarity, he said. . JAMA. read more.

WHO Director-General Tedros Adhanom Ghebreyesus said, Monkeypox keeps spreading. This represents an important development, but it is not sufficient. Because monkeypox belongs to the same family of viruses as the much deadlier smallpox, vaccines and therapeutics stockpiled in the event of smallpoxs return can be used to prevent and treat monkeypox. Indiscriminate use could lead to the emergence of resistant strains. Global.health. All Rights Reserved. Nuzzo JB, Borio LL, Gostin LO. The WHO issued a lengthy list of recommendations on Saturday, broken down into four groups: recommendations for countries that have not yet detected a case of monkeypox; those for countries with ongoing human-to-human transmission; those for countries where the virus is endemic in nature; and those for countries with capacity to produce monkeypox vaccine and therapeutics. At present, the drug should be reserved for individuals in clinical trials or at high risk for severe disseminated disease. Hollie Adams/Getty Images Its very important that we get this balance right.. Commercial and academic diagnostic test developers could augment testing capacity at public health and commercial laboratories by developing new testing technologies, such as point-of-need tests, as well as tests capable of using other specimen types, such as saliva and urine. Authorities have also reported small numbers of women and children infected with monkeypox. Raj Panjabi, director of the White House pandemic preparedness office, said a "coordinated, international response is essential" to stop the spread of the disease and protect communities at the greatest risk of contracting it. Many infections are not linked to other known cases, which indicates links in transmission chains are not being identified. All Rights Reserved. Vaccines and immunization for monkeypox: interim guidance 14 June 2022. In the United States, many of the cases have been diagnosed through sexual health clinics. The Central African Republic and Nigeria two of the countries were monkeypox is endemic have reported five deaths so far in 2022. Monkeypox has been endemic in central and west Africa, but these regions have not been prioritized for vaccine distribution except for sporadic clinical studies. Rosamund Lewis, technical lead for monkeypox at the WHO Health Emergencies Program, said monkeypox appears to be concentrated among men who have sex with men because they have more frequent social gatherings and participate in events involving intimate contact with multiple partners. A systematic review of the epidemiology of human monkeypox outbreaks and implications for outbreak strategy. At the time, the expert group agreed to reconsider their position on the emergency declaration if the outbreak escalated. Spain leads the world in confirmed cases, with more than 3,100 infections, according to tracking by the U.S. Centers for Disease Control and Prevention. All quotes delayed a minimum of 15 minutes. The WHO labeled the coronavirus pandemic a global crisis early in 2020. WHO officials said the global risk of monkeypox is moderate, but that it is high in Europe, where most of the infections have been recorded in an outbreak that ignited in the spring. Reuters provides business, financial, national and international news to professionals via desktop terminals, the world's media organizations, industry events and directly to consumers. The World Health Organization on Saturday declared the monkeypox outbreak a public health emergency. hide caption. The same committee met just one month ago and declined to declare a public health emergency of international concern, or PHEIC. Test tubes labeled "Monkeypox virus positive and negative" are seen in this illustration taken May 23, 2022. The WHO Declaration of Monkeypox as a Global Public Health Emergency. But it could put pressure on the Biden administration to declare monkeypox a public health emergency, which could result in increased funding and compel states and local authorities to report more data to the CDC. Some will break your heart, others will enlighten you. Multi-country monkeypox outbreak: situation update. All Rights Reserved, Challenges in Clinical Electrocardiography, Clinical Implications of Basic Neuroscience, Health Care Economics, Insurance, Payment, Scientific Discovery and the Future of Medicine, Published online July 27, 2022. doi:10.1001/jama.2022.12513. Failure to ensure equitable access will further erode trust in the international system. June 27, 2022. Accessibility Statement, Our website uses cookies to enhance your experience. U.S. monkeypox missteps mirrors early coronavirus response, experts say. The committee members who did not believe an emergency declaration was warranted cited several reasons, including early signs that the outbreak stabilizing. Monkeypox meets all IHR criteria for a PHEIC. Clinical features and management of human monkeypox.

Conflicts of interest comprise financial interests, activities, and relationships within the past 3 years including but not limited to employment, affiliation, grants or funding, consultancies, honoraria or payment, speaker's bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued. Since the role of the committee is to advise, I then had to act as a tie-breaker.. Customize your JAMA Network experience by selecting one or more topics from the list below. read more. The most comprehensive solution to manage all your complex and ever-expanding tax and compliance needs. WHO officials said on Saturday they were exploring the possibility of the virus spreading via new modes of transmission. The window for controlling monkeypox is closing and a well-funded global plan for containment is needed. "Although I am declaring a public health emergency of international concern, for the moment this is an outbreak that is concentrated among men who have sex with men, especially those with multiple sexual partners," Tedros told a media briefing in Geneva. But health officials have stressed that the outbreak could spread to more vulnerable populations, including pregnant women, immunocompromised people, and children. The monkeypox outbreak is largely among men who have sex with men and have multiple sexual partners. At-risk individuals (those with a rash who had recent contact with a person with a similar lesion, or close or intimate contact with individuals in a social network experiencing monkeypox, or recent international travel to countries experiencing outbreaks) should receive education on identifying symptoms and seeking care. The WHO director general emphasized that any containment measures should respect the human rights and dignity of gay and bisexual men. The recommendations call on people to avoid travel if they are experiencing monkeypox symptoms or are under health monitoring because of an exposure to someone who is infected. Transmission among patients other than MSM may be underrecognized due to a lower index of suspicion among clinicians and less frequent testing. Monkeypox has spread across the world at an unprecedented rate in the last two months. Governments must take this more seriously and work together internationally to bring this outbreak under control, Golding said in a statement. Tools to counteract the spread of monkeypox exist. et al. Joint ECDC-WHO Regional Office for Europe monkeypox surveillance bulletin. WHO. Josie Golding, head of epidemics and epidemiology at Britains Wellcome Trust, said this outbreak should be a wake-up call for world leaders to shore up the globes capacity to deal with infectious diseases outbreaks. Governments must take this more seriously and work together internationally to bring this outbreak under control..

Surveillance is expanding, but considerable heterogeneity in case finding among nonendemic countries impairs understanding of true incidence. The information will be posted with your response. There are vaccines available for monkeypox, but those supplies are strained. Four of the six were in men who have sex with men. Given the long incubation period of MPXV and the rapid development of antibodies after vaccination, vaccines may also be administered after exposure to prevent disease. Cases of the viral disease have ballooned since the committee first met at the end of June, when there were only about 3,000 cases. So far, no deaths from the virus have been reported in the United States or Europe, even as case counts have risen. Since May, more than 17300 confirmed and suspected cases of monkeypox have been identified in all 6 WHO regions.2 Outbreaks have been identified primarily among men who have sex with men (MSM).3 As of July 25, CDC reported 3487 confirmed monkeypox/orthopoxvirus cases in the US, but cases are probably significantly underreported.4 The rapid identification of cases across such a large geographic area differentiates current outbreaks from earlier clusters, posing a risk monkeypox virus (MPXV) could become entrenched beyond endemic areas. With monkeypox cases continuing to rise and spread to more countries, we now face a dual challenge: an endemic disease in Africa that has been neglected for decades, and a novel outbreak affecting marginalized communities. During a Washington Post Live interview Friday, CDC Director Rochelle Walensky said inconsistent data inhibits the agencys ability to observe trends in race and ethnicity, sexual behavior and vaccination.

Identify all potential conflicts of interest that might be relevant to your comment. Beer Current clusters represent an extraordinary event as nontravel-associated cases have never been reported outside endemic areas of central and west Africa.1 Given the spread of MPXV to more than 70 countries in 6 WHO regions, this outbreak clearly constitutes a public health risk to other States through the international spread of disease. Given the pace with which cases are being detected and the global scope, the risk that MPXV will become entrenched globally is increasing and a coordinated international response is essential.

Due to the stigma associated with monkeypox, WHO has begun a process to change the name of the virus. Reporting by Jennifer Rigby and Natalie Grover in London, John Revill in Zurich and Timothy Gardner in Washington; Editing by Helen Popper and Daniel Wallis, Bristol Myers drug combo fails to meet main goal in kidney cancer trial, China reports 564 new COVID cases for July 28 vs 626 day earlier, Merck CEO concerned about proposed drug pricing bill hurting innovation, U.S. can conduct 60,000-80,000 monkeypox tests per week, HHS secretary says, Cheap copies of GSK's HIV prevention drug could be ready in 2026, See here for a complete list of exchanges and delays, Declaration is WHO's highest level of alert, Tedros breaks deadlock on advisory committee, Decision welcomed as way to stem disease's spread. To register for email alerts, access free PDF, and more, Get unlimited access and a printable PDF ($40.00), 2022 American Medical Association. Countries with no cases, for instance, were urged to strengthen their surveillance and be prepared to deal with infections if they occur. Privacy Policy| COVID-19 demonstrated the importance of point-of-need testing to ensure rapid test turnaround and timely isolation and contact tracing, and to allow patients to assess their own risks. Monkeypox is endemic only in about a dozen countries in Central and Western Africa. Genomic analyses have identified multiple circulating viral strains, indicating several points of entry for the virus into nonendemic countries and undetected viral spread. According to the U.S. Department of Health and Human Services, 191,000 doses have thus far been delivered to states and city health departments. Monkeypox infections lead to painful lesions and rashes, including vesicles forming on the palms. July 23 (Reuters) - The rapidly spreading monkeypox outbreak represents a global health emergency, the World Health Organization's highest level of alert, WHO Director-General Tedros Adhanom Ghebreyesus said on Saturday. There are more than 16,000 cases globally and according to the Centers for Disease Control, 2,891 cases have been confirmed in the U.S. High-income countries are already negotiating with manufacturers to procure additional vaccine doses, reminiscent of the COVID-19 pandemic. Not all submitted comments are published. S, Walmsley US map & case count. The global health agency was firm in its insistence that this should not happen. For Ron Rivera, the judgment starts with winning or losing. Thats progress. While cases historically have featured broad rashes, cases in the current outbreak have predominantly involved people having just a few genital or anal lesions. Health experts welcomed the WHO's decision to issue the PHEIC declaration, which until now had only been applied to the coronavirus pandemic and ongoing efforts to eradicate polio. In the UK, the drug had to be discontinued in some patients being treated for monkeypox due to liver toxicity.10. While most reported cases exhibit a rash, some patients have few visible lesions. Terms of Use| In short, we have an outbreak that has spread around the world rapidly through new modes of transmission about which we understand too little, WHO Director General Tedros Adhanom Ghebreyesus told reporters Saturday. That means that this is an outbreak that can be stopped with the right strategies in the right groups, Tedros said. "I have decided that the global monkeypox outbreak represents a public health emergency of international concern," WHO Director-General Tedros Adhanom Ghebreyesus said.

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