pomegranate powder drink

2021/05/21

However, anyone with a health condition should check first with a doctor that it is safe for them to increase their consumption of this juice. Pomegranate juice is also rich in compounds called polyphenols, which have anti-inflammatory and antioxidant effects, per a March 2014 report published in Advanced Biomedical Research. Native to Iran and northern India but cultivated for centuries all around the world, the exotic-looking pomegranate fruit is beloved for its thousand jewel-like seeds, known as arils. You can find organic pomegranate powder online ($23.95 on Amazon). If a person with diabetes wishes to consume pomegranate juice, they should do so while keeping their glucose levels within limits agreed with a doctor. Hence, it is free from related heavy metal contamination, pesticide/fungicide residues, and fecal coliform bacteria. Put 3-4 teaspoons of pomegranate powder in your shaker, top with tap water or fruit juice, shake well, and youre all set! And it ended in between the seemingly endless rows of blueberry bushes at Turkey Hill Farm in Haverhill, Massachusetts. Sign up for our mailing list to receive 15% OFF on your next order! Still yummy, though. Drinking pomegranate juice every day may improve learning and memory, according to an older study. Your daily values may be higher or lower depending on your calorie Ash value represents the amount of inorganic salts naturally occurring in the ingredient and adhering to it. Nothing contained herein shall constitute an express or implied What are some of the best BCAAs? One review found evidence of significant drops in blood pressure after consuming pomegranate juice. Learn more here. Transmissible Spongiform Encephalopathies (TSE) and Bovine Spongiform Encephalopathy (BSE) are prion-induced diseases source of which are animals. People with diabetes should check with a doctor about the safest way to incorporate pomegranate into the diet. In this article, learn more about the many health, This article explores how mandarin oranges differ from other types of oranges, their nutritional profile, health benefits, and how to store them, Eating fruit can help ensure a person gets enough fiber, vitamins, and minerals. antioxidant 300g Full of tons of fruit and topped with a fruit skewer, its the ultimate rainbow smoothie! There is just something about rainbow food that makes me feel joyful anyone else feel that?! You must have JavaScript enabled in your browser to utilize the functionality of this website. In addition, pomegranate extract can produce dangerous side effects if taken with angiotensin-converting enzyme (ACE) inhibitors. Research suggests that pomegranate juice may help reduce high blood pressure, which is one of the major risk factors for heart disease, per a January 2017 review in Pharmacological Research.. POM Wonderful Pomegranate Cherry Juice is one popular option ($24.54 for a pack of 6 on Amazon). It is the residue remaining after the incineration of the drug or plant part. It may help with cancer prevention, immune support, and fertility. samples, sell your own products, and chat with our experts. The intake of this fruit is good for heart, gut, and skin health. guarantee or warranty with respect to Green Jeeva, LLCs or their use. Pomegranate juice is rich in potassium, which might pose a problem for people with chronic kidney disease, according to the National Kidney Foundation. They also observed that the structure of the new skin was well-formed and that there were few inflammatory cells in the area. These products are not intended to diagnose, treat, cure, or prevent any disease. Use single quotes (') for phrases. For example, the drink may interact with certain medications, so some people are advised to sip on an alternative beverage. With their antioxidative, anti-inflammatory, ergogenic (enhancing physical performance), and sexual health-supporting properties, this fruit will be a fabulous addition to anyones diet. prevents it from being broken down through oxidation, enhance physical performance and speed up post-exercise recovery, duration and strength of erections in males, Top 5 nitric oxide boosting fruits and vegetables. The antioxidants in fruits can help reduce levels of reactive oxygen species (ROS), a type of free radical, in the body. You can feel good knowing that when you reach for Carrington Farms, youre reaching for better. Please place your Bid. Remember, all adjustments made to your diet should be undertaken after consulting with a medical professional. People with diabetes who drank 1.1 cups (250 ml) of pomegranate juice daily lowered two inflammatory markers CRP and interleukin-6 by 32 and 30 percent, respectively, according to one March 2014 study in the Journal of Research in Medical Sciences. Use spaces to separate tags. 2022 Greenjeeva . Also, remember that pomegranate juice is extremely dangerous for your clothes if youre clumsy or have bad luck. Even so, it's important to remember that pomegranate juice lacks fiber and contains a lot of sugar, a combination that may counter your weight loss goals. The researchers suggest that pomegranate could have a role in treating Alzheimers disease. Antioxidants help remove ROS from the body. We provide Organic Pomegranate Juice Powder with a moisture content of NMT 5%. The supplement may also interact negatively with certain medications. Pomegranate juice is rich in punicalagins, which are extremely powerful antioxidants. LIVESTRONG.com may earn compensation through affiliate links in this story. Powerful. diet. Its antioxidant properties can boost overall health and may help reduce the risk of some conditions. All production facilities are HACCP compliant and strictly follow current Good Manufacturing (cGMPs). any liability or risk involved in the use of its products since the conditions of use Polyphenols have anti-inflammatory and antioxidant properties. Pomegranate seeds are safe to eat and rich in antioxidants, fiber, and many vitamins. Packing all the benefits of raw pomegranate in a convenient to eat form, this all-natural supplement can be used in many different ways too! Medical News Today has strict sourcing guidelines and draws only from peer-reviewed studies, academic research institutions, and medical journals and associations. Beautiful 7 layer rainbow smoothie recipe! The inspiration for this blueberry explosion of a smoothie bowl started with a blogging retreat to Minneapolis, Minnesota. samples, sell your own products, and chat with our experts. If you eat fruit bowls regularly, try topping them with a few teaspoons of pomegranate powder for added benefits and extra flavor. Further studies are now underway, according to the American Cancer Society. Basically, the only problem with eating pomegranate is that its not very convenient. Does the coming winter have you feeling down? Its probably because rainbows bring about thoughts of sunshine, spring, and baby animals.. hahaha :), Only registered users can write reviews. The antioxidant content of pomegranate powder is similar to that of fresh pomegranate juice, although the powder takes longer to reach maximum effect, according to a June 2008 study in the Journal of Medicinal Food. (3), Probiotics To a great extent, your blood pressure is defined by the inner diameter of your arteries. Pomegranate juice may help lower blood pressure and protect the heart and arteries. Pomegranate juice powder is made from dehydrated pomegranate juice, so it has much of the same nutritional content as the fresh fruit (though some research shows certain nutrients, namely vitamin C, may be decreased in the dehydrating process). Pomegranate's benefits also include antimicrobial effects. are beyond our control. Strong Anti-Inflammatory Effects - Chronic joint pain can be debilitating, to say the least. In a 2019 investigation, cyclists who consumed pomegranate took significantly longer to reach a point of exhaustion than those who did not. As a source of polyphenols, pomegranate could be suitable for treating various inflammatory conditions. We test total heavy metals, lead, arsenic, mercury, and cadmium in our products. Jam-packed with general health benefits AND a few extra perks for men, pomegranate should be a permanent point on your shopping list. In the Middle East, people traditionally consider pomegranate a medicinal plant and treatment for diabetes, and some evidence supports this. Cookies, cakes, pies, cheesecakes, loads and loads of incredible dishesdelicious and at least somewhat healthy. For example, you can add it to your smoothies or preworkout blends, brew some tea or bake some cookies, use it as a fruit bowl toppingor get creative and create something amazing. request for Besides dehydrated pomegranate powder, pomegranate cherry juice is another popular pom-related product available on the market. Let's take a close look at key benefits of pomegranate powder as part of your regular diet. The end application of the product generally helps in determining which mesh size is suitable to buy. Some older research suggests that the antioxidant activity in pomegranate could benefit people with type 2 diabetes. Additional research suggests that drinking pomegranate juice may hold promise for preventing preeclampsia, growth restriction and preterm birth, per May 2012 research in the American Journal of Physiology, Endocrinology and Metabolism. So we provide an ash value of less than 5%. Older studies suggest oxidative stress can lead to sperm dysfunction in males and reduced fertility in females. Some people have reported diarrhea and allergic reactions. Between the pandemic and its corresponding economic struggles, we might all be feeling a bit of pressure. Ingredients in pomegranate may also help prevent breast, lung, and skin cancer. Cherries contain many of the same health benefits as pomegranates, so if you enjoy their taste, you might want to taste test the combination. It is best to check with a doctor before increasing the amount of pomegranate juice a person consumes to make sure it will not interfere with any medications they are taking. The antioxidative power of pomegranate means that this fruit effectively captures a lot of free radicals that appear in the tissues of the body during any kind of damage, inflammation, as well as during normal aging (thats why pomegranate is considered to be an anti-aging fruit too.). You might consider eating the whole fruit rather than drinking the juice, because the fiber prevents a spike in blood sugar that can result from ingesting the natural sugars, according to Harvard Health Publishing. Now, the most effective way your body has of keeping your arteries functional and your blood pressure healthy is through the action of nitric oxide (NO), a small molecule that relaxes the wall of your blood vessels. In today's complex world, health and resilience against illness is on everyone's minds. While pomegranate juice is packed with vital nutrients, there is insufficient evidence that it helps directly with weight loss. information, request for on 10th Dec 2020. Preformulation studies will help in the selection of a particular mesh size. Since pomegranate has prominent antioxidative effects, it quickly helps in relieving inflammation of any kind in the body but works especially well in the stomach and guts. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. Craft Superfood Smoothies For Quick Nutrition - When you shop for an, Improve Your Memory Through Polyphenols - If it feels like 2020 has passed by in a blur, we don't blame you. Pomegranate powder contains both punicalagin and punicic acid, two powerful. From reducing inflammation to lowering cholesterol levels, pomegranate juice has been linked to a number of health benefits. Policy. It shouldn't be taken with the blood thinner warfarin, says the Memorial Sloan Kettering Cancer Center. We strive to make accessible innovative, simple, clean, and real products that not only taste great, but kick your nutrition up a notch. Somewhat because usually these recipes contain sugar and flour, so theyre more pleasant than beneficial for your health. The rat pups from mothers that drank pomegranate juice showed less damaged brain tissue after being deprived of oxygen for 45 minutes. 2004-2022 Healthline Media UK Ltd, Brighton, UK, a Red Ventures Company. People have used pomegranate for centuries for its antimicrobial properties. In their study, researchers fed pomegranate juice to rats during the last trimester of pregnancy and while the newborn rats fed from their mothers. It concluded that the juice markedly decreases the risk. In a 2016 clinical trial, 38 people with OA of the knee consumed either pomegranate juice or no juice for 6 weeks. All Rights Reserved. (70), Herbal Ingredients The organic pomegranate fruit juice powder that we provide is pink fine powder, with strong fruit characteristic odor nature. However, the National Center for Complementary and Integrative Health notes that the root, stem, and peel contain substances that may be harmful. (21), Register As ", National Kidney Foundation: "Reach for a Glass and Your Body May Benefit", Memorial Sloan Kettering Cancer Center: "Pomegranate", Journal of Research in Medical Sciences: "Effects of pomegranate juice consumption on inflammatory markers in patients with type 2 diabetes: A randomized, placebo-controlled trial", Journal of Agricultural and Food Chemistry: "Antioxidant activity of pomegranate juice and its relationship with phenolic composition and processing", Pharmacological Research: "Effects of pomegranate juice on blood pressure: A systematic review and meta-analysis of randomized controlled trials", Journal of Medicinal Food: "Pomegranate juice and extracts provide similar levels of plasma and urinary ellagitannin metabolites in human subjects", Nutrition: "Obesity: the preventive role of the pomegranate (Punica granatum)", Pediatric Research: "Maternal Dietary Supplementation with Pomegranate Juice Is Neuroprotective in an Animal Model of Neonatal Hypoxic-Ischemic Brain Injury", American Journal of PhysiologyEndocrinology and Metabolism: "Pomegranate juice and punicalagin attenuate oxidative stress and apoptosis in human placenta and in human placental trophoblasts". In keeping with our commitment to holistic well-being, Zint is proud to present Immune Strength, our new line of incredible organic superfoods from around the globe, boasting powerful immune support benefits for the most potent nutritional protection found in nature. Want high volume of this product? As a result, we cannot show you the price in catalog or the product page. We also ensure that our product complies with California prop 65 regulations for lead content below 0.5 ppm levels. Thats right, pomegranate, closely followed by other berries (blueberry, blackberry, raspberry, and so on). You can learn more about how we ensure our content is accurate and current by reading our. Rasheed, Z. This experiment did not involve drinking pomegranate juice, but it is further evidence of the pomegranates healing properties. Studies in humans are underway to investigate whether pomegranate juice can improve markers of inflammation in people with IBD. More research needs to be conducted, but preliminary investigations suggest it may help fight prostate, breast, lung, colon and skin cancers. No, E.coli, Staphylococcus & Salmonella are not present in this ingredient. Our nutrient-rich supplements have unique propertiesto get you looking andfeeling your best! They grow up to 33 feet tall and originated primarily from Iran and Northern India. Weird, juicy, very red, and incredibly nutritious. We ensure our products are free from such toxic chemicals or within required residual limits. STOCK UP ON ALL YOUR CARRINGTON FARMS PRODUCTS, Key Health Benefits of Pomegranate Powder, Brimming With Powerful Antioxidants - One of the primary benefits of pomegranate powder is its powerful array of antioxidants. The juice protects cholesterol from oxidation, which reduces the development of atherosclerotic plaque, and the likelihood of its consequences such as heart attacks and stroke. While studies seem to suggest that drinking pomegranate juice might lower cholesterol, the overall evidence is mixed, according to the Mayo Clinic. Posted by Carrington Farms Some scientists have suggested including pomegranate juice as a routine part of the diet, as it has cardiovascular and other benefits. Now, pomegranates are one of the healthiest fruits available to the general public. Healthy blood pressure through healthy levels of nitric oxide! (3), Vitamins Series (50), Food & Formulation Additives An older, 2014 research article notes that the polyphenols in pomegranate may aid in preventing the growth of cancer cells related to prostate cancer. Pomegranate powder can help you refuel your skin with a dash of vitamin C. You can enjoy visibly hydrated skin that looks good with improvement to both texture and brightness. The authors found evidence that ingredients in pomegranate helped restore the activity of certain enzymes. Pomegranate (Punica granatum) has been cultivated since ancient times in Iran and India, slowly making its way to the Americas by the 16-18th century. The body produces ROS during metabolism and other processes. The result? Our price is lower than the manufacturer's "minimum advertised price." Juicing to lower cholesterol is a practice some people swear by, but it's not a remedy that's been proven to work for everyone. Nitric oxide is great for a lot of things besides maintaining healthy blood pressure levels. However, a person should check with a doctor to ensure it is safe to consume within their meal plan. However many fruits are high in natural sugars and may not be. Sweet and tart, our pomegranate juice powder is a versatile ingredient that can be added to smoothies, drinks, yogurts, dressings, and more! Pomegranate juice is full of antioxidants and other healthy nutrients. Research from 2014 has found that drinking pomegranate juice may increase the quality and motility of sperm. Pomegranate juice contains polyphenols, protein, and other mineral substances like calcium, potassium, phosphorus, etc. Serving In addition, blood tests showed they had higher antioxidant activity. One pomegranate contains around 39 grams of sugar. Not great. Its simple: if you want to live better, you need to feel better from the inside out! According to the authors of a 2017 review, evidence from rodent studies suggests that pomegranate extract might benefit people with conditions such as: Molecular studies have indicated that ingredients in pomegranate extract could silence some of the genetic signals that contribute to osteoarthritis (OA). We generally test total plate count (TPC), Yeast and mold, E Coli & Salmonella in our products. An older research article from 2012 found that pomegranate juice could reduce oxidative stress in the cardiovascular system and lower the risk of: Drinking pomegranate juice daily may help lower systolic blood pressure. It features all the health benefits of this wonderful fruit in the most convenient and delicious way possible. Sweet. Oranges may help lower the risk of stroke, support the heart and skin, and aid diabetes management. In the United States, pomegranates grow in California. Pomegranate powder's health benefits reflect those of the drink. What are the health benefits of pomegranate? The Pomegranate Council calls them the jewel of autumn, as this is when they are in season. In an older study, mice consumed either a control diet or one that was 4% pomegranate. Pomegranate is a fruit that contains antioxidants and anti-inflammatory substances. Sprinkling pomegranate seeds in a salad, for example, will provide the antioxidants, without taxing the body to process the sugar content. Of course, more evidence is needed to support these benefits for human infants. Some researchers suspect that pomegranate juice may block or slow the buildup of cholesterol in the arteries of people who are at higher risk of heart disease. Should You Drink Pomegranate Juice to Lower Cholesterol? It is filled with antioxidants that support the body in many ways by fighting the free radicals in the body. This is especially important because pomegranate juice may interfere with certain medications. Prostate cancer, nutrition, and dietary supplements (PDQ)health professional version (2022). There is not enough evidence to show that pomegranate can fight pathogens in humans. Oxidative stress may contribute to metabolic disease, cancer, and other health issues. These heavy metals by numerous studies are purported to be toxic for human consumption beyond certain limits and are known carcinogens. It's not hard to see why people would be shopping for superfoods after the year that 2020 has been. The authors note that regular consumption of this juice could be part of a heart-healthy diet. Here are some questions people often ask about pomegranate. Pomegranate stains can be permanent, sorry! That said, pomegranates could be helpful for maintaining a healthy weight. Now tremendously popular around the world, with particular reverence in the Middle East and Southeast Asia, pomegranates are revered as a true superfood. While pomegranate powders have been proven effective numerous times over, they still should be added to a well-rounded diet. Most people can safely drink a serving of pomegranate juice most days as part of a varied diet. Moisture content NMT 5% in our product ensures better control of microbial growth and in turn, increased shelf life. Thanks to the health benefits mentioned above (antioxidative potential, anti-inflammatory action, nitric oxide boosting properties), pomegranate can significantly enhance physical performance and speed up post-exercise recovery. Size: 100g. In mouse studies, researchers linked pomegranate fruit extract with a reduction in prostate-specific antigen levels and the inhibition of tumor growth. However, it is worth noting that some individuals have experienced diarrhea, a symptom of IBD, after consuming pomegranate. Motility is the movement that sperm needs to reach the egg. Guess what fruit won the first place? One unique way to provide an array of physical and mental benefits is by adding pomegranate powder to your diet. Again, more studies are needed to confirm these potential benefits. Buyer, Register As Pomegranates are borne from fruit-bearing shrubs within the Lythraceae family. Oh, and did you know you can take it in a lot of different ways too? Now, pomegranate may be a superfruitbut there are tons of other healthy fruits out there, each with its own fabulous health benefits and unique nutrients. Visibly Rejuvenate Your Skin - Are you struggling with dull or dry skin? Of course, you could just go for pomegranate juicebut then youd be missing on all those healthy antioxidants and polyphenols from the seeds and peel of the fruit. If youre of the type of people who prefer a hot drink to a cold and frothy one, try brewing some pomegranate juice! Pomegranate juice is safe for most people to consume. Here, we'll look at the health benefits of pomegranate juice, how much sugar is in pomegranate juice, whether pomegranate juice benefits weight loss and some additional information about the tart and tasty drink. Pomegranate juice may have a range of beneficial properties. While drinking fruit juice daily is linked to a higher risk of diabetes, eating two servings of fruit per week is shown to lower the risk of diabetes, per Harvard Health Publishing. According to a 2018 review, compounds present in pomegranate may help improve exercise performance and help with post-exercise recovery. If at any time within 30 days after your purchase, for any reason, youre not happy with this productwell refund your money. We accept ash value below 5% because more content of ash value represents more impurities which adversely affect human health when consumed. Whats new in prostate cancer research? Some researchers have used the flowers and extract of pomegranate to heal wounds, noting a significant decrease in the size of wounds treated in this way. They increase caloric intake, which decreases the cardiovascular benefits. For instance, by relaxing the blood vessels and therefore enhancing local blood flow, nitric oxide significantly improves the duration and strength of erections in males. While the juice can be a refreshing choice, there are some drawbacks. A 2021 review of 12 human, animal, and laboratory studies concludes that pomegranate extract could benefit people with RA due to its anti-inflammatory and antioxidant properties. The moisture content of the product facilitates the growth of microorganisms in the product which in turn increases the risk of biological hazards. In 2021, however, some laboratory tests suggested that compounds in pomegranate could help fight a mosquito-borne virus known as Mayaro virus. Buyer, Bitter Melon Extract Powder 10% Charantin Uv, Lactobacillus bulgaricus powder 50 B CFU/G, - Shipping/ Return Pomegranate juice and cholesterol also appear to share a positive relationship: A handful of small studies suggest that drinking the juice may help lower levels of bad cholesterol, according to the Mayo Clinic, though more research is needed. * These statements have not been evaluated by the Food and Drug Administration. Not only is it exquisite in flavor, it offers natural support for immune health and many other potential benefits to your well-being and vitality. It also includes inorganic matter which helps to identify adulteration. While drinking pomegranate juice may help lower cholesterol levels, the Mayo Clinic recommends people speak with their doctor before drinking it with that purpose in mind. Yes, Californias Safe Drinking Water & Toxic Enforcement Act of 1986 is commonly known as Proposition 65 (Prop 65), which establishes a list of chemicals that the state of Californias risk assessment process has determined to present a risk of cancer, birth defects or other reproductive harm. All rights reserved. Here's how the juice and the whole fruit measure up: As evident in the chart above, the main difference between drinking the juice and eating the fruit is that the fruit is a rich source of fiber. Read on to learn more about BCAAs, such as effectiveness, side effects, and a list of products to try. Historically, people have associated pomegranate with fertility and abundance. Address : 2610 W Horizon Ridge Pkwy, Suite 201A, Henderson, NV 89052, Organics Intake of pomegranate prevents the onset of osteoarthritis: Molecular evidences. Pomegranate juice is generally safe to drink just make a point check the label to ensure it's 100 percent juice you're consuming, advises the Mayo Clinic. (n.d.). Head over to Carrington Farms to shop our organic pomegranate powder and selection of superfoods and healthy grains and seeds. We link primary sources including studies, scientific references, and statistics within each article and also list them in the resources section at the bottom of our articles. Because of these findings, researchers suggest that consuming pomegranate juice during pregnancy may protects infants' brains. We avoid using tertiary references. Botanical Name:Punica granatum Plant Part Used:Fruits Processing Method: Drying, GrindingPomegranates is generally eaten ripen, also used in food, and beverages, and also a functional additives for health care products. Possible benefits of pomegranate juice include being an antioxidant, which may help prevent cancer and other conditions, providing vitamin C, boosting digestive health, and reducing insulin resistance. Pomegranate juice and weight loss are are sometimes linked to each other. In the study, 32 people consumed either 8 ounces of pomegranate juice or other drink for 8 weeks. With the regular addition of pomegranate to your diet, consumers can enjoy a reduction in symptoms relating to inflammation. National Center for Complementary and Integrative Health, Complementary Medicine / Alternative Medicine, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7867005/, http://synapse.koreamed.org/DOIx.php?id=10.5534/wjmh.2014.32.1.1, http://link.springer.com/article/10.1186/1477-7827-10-49, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296487/, https://pubmed.ncbi.nlm.nih.gov/30350760/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514854/, https://pubmed.ncbi.nlm.nih.gov/23684435/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3736548/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622718/, https://pubmed.ncbi.nlm.nih.gov/26804926/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671682/, https://pubmed.ncbi.nlm.nih.gov/32951728/, https://pubmed.ncbi.nlm.nih.gov/33400368/, https://nccih.nih.gov/health/pomegranate/at-a-glance, https://fdc.nal.usda.gov/fdc-app.html#/food-details/169134/nutrients, https://www.cancer.gov/about-cancer/treatment/cam/hp/prostate-supplements-pdq#section/_162, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4825888/, https://pubmed.ncbi.nlm.nih.gov/27888156/, https://parasitesandvectors.biomedcentral.com/articles/10.1186/s13071-021-04955-4, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554985/, https://www.ncbi.nlm.nih.gov/books/NBK541064/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4220500/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521089/, https://www.myplate.gov/eat-healthy/fruits, https://www.cancer.org/cancer/prostate-cancer/about/new-research.html, https://pubs.acs.org/doi/10.1021/acschemneuro.5b00260, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007340/.