magnesium hydroxide dosage for adults

2021/05/21

Iron: (Moderate) Doses of antacids and iron should be taken as far apart as possible to minimize the potential for interaction. Separate the administration of atazanavir and antacids to avoid the potential for interaction; give atazanavir 2 hours before or 1 hour after the antacid. Dichlorphenamide: (Moderate) Use dichlorphenamide and magnesium hydroxide together with caution. (Moderate) Concurrent administration of rilpivirine and antacids may significantly decrease rilpivirine plasma concentrations, potentially resulting in treatment failure. Although the exact mechanism is not known, theoretically it may be due to alterations in gastric pH. Antacids may decrease the absorption of oral iron preparations. Monitor serum potassium levels to determine the need for potassium supplementation and/or alteration in drug therapy. Acetaminophen; Dextromethorphan; Phenylephrine: (Minor) Antacids can delay the oral absorption of acetaminophen, but the interactions are not likely to be clinically significant as the extent of acetaminophen absorption is not appreciably affected. Closely monitor patients for changing analgesic requirements or adverse events. One case of grand mal seizure has been reported in a patient with chronic hypocalcemia of renal failure who was given sodium polystyrene with magnesium hydroxide as laxative. Studies suggest that oral, nonabsorbable antacids and/or laxatives like magnesium hydroxide can interfere with the decrease in colon pH necessary for lactulose's action and these alterations may make it challenging to titrate an accurate dose of lactulose during treatment of hepatic encephalopathy. Increased urine alkalinity also can inhibit the conversion of methenamine to formaldehyde, which is the active bacteriostatic form; concurrent use of methenamine and urinary alkalizers is not recommended. Taking these drugs simultaneously may result in reduced oral bioavailability of cabotegravir. Lactulose: (Major) In general, other laxatives should not be used concurrently with lactulose, especially during the initial phase of therapy for portal-systemic encephalopathy, because the loose stools resulting from their use may falsely suggest that adequate lactulose dosage has been achieved. Cefdinir: (Moderate) Antacids containing magnesium or aluminum can interfere with the absorption of cefdinir. Naproxen; Esomeprazole: (Minor) Concomitant administration of antacids can delay the absorption of naproxen. Coadministration may impair absorption of tetracycline which may decrease its efficacy.

Ketoconazole: (Moderate) Administer antacids at least 1 hour before or 2 hours after taking ketoconazole. Check with your physician for additional information about side effects. Chlorpromazine: (Moderate) The absorption of chlorpromazine liquids, suspensions, or concentrates may be decreased by co-administration of antacids. The onset of laxative action of magnesium hydroxide ranges between 30 minutes and 8 hours. Examples of compounds that may interfere with quinolone bioavailability include antacids that contain magnesium hydroxide. In general, it would be illogical to concurrently administer these drugs at the same time. Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine: (Minor) Antacids can delay the oral absorption of acetaminophen, but the interactions are not likely to be clinically significant as the extent of acetaminophen absorption is not appreciably affected. Therefore, if concomitant administration of these agents is indicated, dosing should be separated by 2 hours. Budesonide: (Moderate) Enteric-coated budesonide granules dissolve at a pH more than 5.5. What Are the Best PsA Treatments for You? Likewise, the dissolution of the coating of extended-release budesonide tablets (Uceris) is pH dependent. (Minor) Antacids may decrease the peak plasma concentration (Cmax) of total ezetimibe by 30%. [42282] [45899]. Bismuth Subsalicylate; Metronidazole; Tetracycline: (Moderate) Separate administration of tetracycline and antacids by 2 to 3 hours. Antacids containing alkalinizing agents such as sodium bicarbonate can alkalinize the urine, thereby decreasing the effectiveness of methenamine by increasing the amount of non-ionized drug available for renal tubular reabsorption. Administer hydroxychloroquine and antacids at least 4 hours apart. Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine: (Minor) Antacids can delay the oral absorption of acetaminophen, but the interactions are not likely to be clinically significant as the extent of acetaminophen absorption is not appreciably affected. Consider closely monitoring blood glucose concentrations. Increased urine alkalinity also can inhibit the conversion of methenamine to formaldehyde, which is the active bacteriostatic form; concurrent use of methenamine and urinary alkalizers is not recommended. The simultaneous administration of an antacid with dasatinib decreased the Cmax and AUC of dasatinib by 58% and 55%, respectively. Antacids such as aluminum hydroxide/magnesium hydroxide decrease riociguat absorption. Monitor clinical response, and adjust propranolol dosage if needed to attain therapeutic goals. Ethotoin: (Major) Magnesium hydroxide inhibits the absorption of ethotoin. Moxifloxacin absorption may be reduced as quinolone antibiotics can chelate with divalent or trivalent cations. Acetaminophen; Oxycodone: (Minor) Antacids can delay the oral absorption of acetaminophen, but the interactions are not likely to be clinically significant as the extent of acetaminophen absorption is not appreciably affected. Not for non-prescription use. Gabapentin: (Moderate) Gabapentin should be taken at least 2 hours after the administration of antacids.

The chemical structure of these GI drugs that contain polyvalent cations, such as magnesium hydroxide, can bind dolutegravir in the GI tract. Lansoprazole; Naproxen: (Minor) Concomitant administration of antacids can delay the absorption of naproxen. If the patient requires magnesium supplements or a magnesium-containing antacid, it may be wise to separate the administration of phosphates from magnesium-containing products. Ezetimibe: (Minor) Antacids may decrease the peak plasma concentration (Cmax) of total ezetimibe by 30%. Levofloxacin: (Moderate) Administer magnesium hydroxide at least 2 hours before or 2 hours after orally administered levofloxacin. Rosuvastatin: (Moderate) Coadministration of rosuvastatin with antacids has reduced rosuvastatin plasma concentrations by 54%. Register Now. Moxifloxacin: (Major) Administer oral moxifloxacin at least 4 hours before or 8 hours after magnesium hydroxide. Antacids containing alkalinizing agents such as sodium bicarbonate can alkalinize the urine, thereby decreasing the effectiveness of methenamine by increasing the amount of non-ionized drug available for renal tubular reabsorption. Simultaneous administration should be avoided; separate dosing by at least 2 hours to limit an interaction. Budesonide; Formoterol: (Moderate) Enteric-coated budesonide granules dissolve at a pH more than 5.5. Acetaminophen; Caffeine: (Minor) Antacids can delay the oral absorption of acetaminophen, but the interactions are not likely to be clinically significant as the extent of acetaminophen absorption is not appreciably affected. Halofantrine: (Major) The oral absorption of halofantrine may be hindered by the concomitant use of antacids, and perhaps other antacids. Simultaneous oral administration should be avoided when feasible; separate dosing by at least 2 hours to limit an interaction. Sodium Ferric Gluconate Complex; ferric pyrophosphate citrate: (Moderate) Doses of antacids and iron should be taken as far apart as possible to minimize the potential for interaction. Concomitant administration with high doses of antacids reduces peak plasma concentrations by 24% and the extent of absorption by 27%. Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate: (Major) The therapeutic action of methenamine requires an acidic urine. Conjugated Estrogens; Bazedoxifene: (Minor) In clinical evaluation, a single dose of 460 mg aluminum hydroxide and 400 mg magnesium hydroxide was given with a bazedoxifene 40 mg tablet in 30 postmenopausal women after an overnight fast. Patients who received concomitant oral sodium polystyrene sulfonate and non-absorbable cation-donating antacids and laxatives have developed systemic alkalosis. Although the magnitude of the interaction is not great, an occasional patient may be affected and the interaction may lead to subtherapeutic phenytoin concentrations. Delafloxacin: (Major) Administer oral delafloxacin at least 2 hours before or 6 hours after products that contain magnesium hydroxide. Bictegravir; Emtricitabine; Tenofovir Alafenamide: (Moderate) Administer bictegravir on an empty stomach 2 hours before or 6 hours after taking antacids containing aluminum or magnesium. Although this finding is of marginal clinical significance, patients should be monitored for adverse effects in this situation. Selpercatinib: (Major) Avoid coadministration of selpercatinib with antacids due to the risk of decreased selpercatinib exposure which may reduce its efficacy. Coadministration of aluminum/magnesium hydroxide and bazedoxifene decreased Cmax of bazedoxifene by 8% and increased AUC of bazedoxifene by 7%. Magnesium may cause tocolysis in late pregnancy, but this is not a risk with the occasional use of over-the-counter preparations. Administer chloroquine and antacids at least 4 hours apart. document.write(new Date().getFullYear()) PDR, LLC. Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine: (Minor) Concurrent use of hydrocodone with strong laxatives that rapidly increase gastrointestinal motility, such as magnesium hydroxide, may decrease hydrocodone absorption. Bumetanide: (Moderate) Loop diuretics may increase the risk of hypokalemia especially in patients receiving prolonged therapy with laxatives. Sucralfate: (Moderate) Antacids can interfere with the binding capacity of sucralfate to the GI mucosa, decreasing its effectiveness. Octreotide: (Moderate) Coadministration of oral octreotide with antacids may require increased doses of octreotide. Coadministration may impair absorption of demeclocycline which may decrease its efficacy. The effect of the antacids in this regard is not expected to have a significant effect on the ability of ezetimibe to lower cholesterol. Magnesium and aluminum hydroxide antacids may increase the blood concentration of tacrolimus. Examples of cation-donating antacids and laxatives include aluminum hydroxide, calcium carbonate, magnesium carbonate, magnesium citrate, and magnesium hydroxide. Monitor serum potassium levels to determine the need for potassium supplementation and/or alteration in drug therapy. Taking these drugs simultaneously may result in reduced oral bioavailability of cabotegravir. Ofloxacin absorption may be reduced as quinolone antibiotics can chelate with divalent or trivalent cations. Hypermagnesemia has been reported in newborns whose mothers were using magnesium-containing antacid products chronically in high doses. Antacids can impair the absorption of ketoconazole. Copyright 2022 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. Ingestion times of phenytoin capsules and calcium antacids should be staggered in patients with low serum phenytoin levels to prevent absorption difficulties. Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide: (Minor) Antacids can delay the oral absorption of acetaminophen, but the interactions are not likely to be clinically significant as the extent of acetaminophen absorption is not appreciably affected. What Are Side Effects Associated with Using Magnesium Hydroxide? However, to limit any potential interaction, it would be prudent to administer ezetimibe at least 1 hour before or 2 hours after administering antacids. If coadministration with antacids is necessary, administer sotorasib 4 hours before or 10 hours after an antacid. Erlotinib displays pH-dependent solubility with decreased solubility at a higher pH; the increased gastric pH resulting from antacid therapy may reduce the bioavailability of erlotinib. Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide: (Moderate) Separate administration of elvitegravir and antacids by at least 2 hours. In addition, some antacids like calcium carbonate, share the potential with the citrate salts for development of metabolic alkalosis, when given in higher dosage. Emtricitabine; Rilpivirine; Tenofovir alafenamide: (Moderate) Concurrent administration of rilpivirine and antacids may significantly decrease rilpivirine plasma concentrations, potentially resulting in treatment failure. Coadministration may decrease infigratinib exposure resulting in decreased efficacy. Mefenamic Acid: (Moderate) Ingestion of mefenamic acid with antacids is not recommended. Hydrocodone; Potassium Guaiacolsulfonate: (Minor) Concurrent use of hydrocodone with strong laxatives that rapidly increase gastrointestinal motility, such as magnesium hydroxide, may decrease hydrocodone absorption. Staggering the times of administration may avoid this pharmacokinetic interaction. If these drugs must be used together, give glipizide at least 2 hours prior to the antacid. In a drug interaction study, the AUC for raltegravir was decreased by 49% (90% CI, 35% to 60%), 51% (90% CI, 33% to 65%), and 30% (90% CI, 4% to 50%), when administered with, 2 hours before, and 2 hours after aluminum/magnesium hydroxide antacids, respectively. Closely monitor patients for changing analgesic requirements or adverse events. dehydration / Delayed / Incidence not knownhypermagnesemia / Delayed / Incidence not known, diarrhea / Early / Incidence not knownnausea / Early / Incidence not knowndiuresis / Early / Incidence not knownvomiting / Early / Incidence not known. The mechanisms by which antacids reduce phenytoin absorption may involve increased gastric transit time, chelation, adsorption, and/or altered solubility. Dolutegravir; Lamivudine: (Moderate) Administer dolutegravir 2 hours before or 6 hours after taking cation-containing gastrointestinal medications such as magnesium hydroxide. Magnesium hydroxide is used to treat constipation and acid indigestion. It may be advisable to separate chlorpromazine administration from antacids by 1 to 2 hours. Propranolol: (Moderate) Antacids may reduce the absorption of propranolol. In general, it may be prudent to avoid drugs such as antacids in combination with enteric-coated budesonide. Taking these drugs simultaneously may result in reduced bioavailability of dolutegravir. This interaction may be due to surface absorption of the antibacterial onto the antacid. Check with your physician if you have health questions or concerns. Closely monitor patients for changing analgesic requirements or adverse events. Normally, antacids like magnesium hydroxide and calcium carbonate neutralize hydrochloric acid in the stomach, forming magnesium chloride and calcium chloride. Antacids containing alkalinizing agents such as sodium bicarbonate can alkalinize the urine, thereby decreasing the effectiveness of methenamine by increasing the amount of non-ionized drug available for renal tubular reabsorption. In healthy subjects, the AUC of acalabrutinib was decreased by 53% when acalabrutinib was coadministered with another antacid. Although the exact mechanism is not known, theoretically it may be due to alterations in gastric pH. The chemical structure of these GI drugs that contain polyvalent cations, such as magnesium hydroxide, can bind dolutegravir in the GI tract. Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine: (Minor) Antacids can delay the oral absorption of acetaminophen, but the interactions are not likely to be clinically significant as the extent of acetaminophen absorption is not appreciably affected. Separate the administration of bosutinib and antacids by more than 2 hours. Hydrocodone; Ibuprofen: (Minor) Concurrent use of hydrocodone with strong laxatives that rapidly increase gastrointestinal motility, such as magnesium hydroxide, may decrease hydrocodone absorption. Antacid administration two hours after the sotalol dose does not alter sotalol pharmacokinetics or pharmacodynamics. Butalbital; Acetaminophen; Caffeine: (Minor) Antacids can delay the oral absorption of acetaminophen, but the interactions are not likely to be clinically significant as the extent of acetaminophen absorption is not appreciably affected.